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The direct path through the basal ganglia.

Direct switching pathway from the cortex through the basal ganglia towards the thalamus

The "direct pathway" from the cortex through the basal ganglia towards the thalamus can originate anywhere in the cerebral cortex, but usually in the forehead, crown and lobe cortex and runs via switching in the striatum's D1 neuron directly into the GPi-SNr.

In short, it can be said that activity along the "Direct Path" means an increase in motor skills.

When the nerve cells (MSNs) in the striatum, which are inhibitory (constricting) and equipped with dopamine receptors of type D1, are excited (driven on) by the signals from the cerebral cortex, their inhibitory effect on GPi-SNr increases. This, in turn, leads to a reduction in the braking of the GPi-SNr on the thalamus. The thalamus is disinhibited! The signal flow from the thalamus to the cerebral cortex is affected and increased! Motor skills are facilitated.

The release of dopamine from SNc in the striatum has a similar activating effect on the D1-endowed neurons and amplifies signaling along the "Direct Pathway".

Normal activity along the "direct pathway" thus means increased signal flow from the thalamus to the cerebral cortex with positive effects on motor skills.

The nerve impulse flows along the direct, hyperdirect and indirect pathways are intertwined and coordinated from SNc.
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